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Publications

Important recent publications

• Jung K, Grade M, Gaedcke J, Jo P, Opitz L, Becker H, Ghadimi BM, Beißbarth T (2010). A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data. Computer Methods and Programs in Biomedicine, 100:132-139.
• Bender C, Henjes F, Fröhlich H, Wiemann S, Korf U, Beißbarth T (2010). Dynamic Deterministic Effect Propagation Networks: learning signalling pathways from longitudinal protein array data. Bioinformatics, 26(18):i596-i602.
• Johannes M, Brase JC, Fröhlich H, Gade S, Gehrman M, Fälth M, Sültmann H, Beißbarth T (2010). Integration Of Pathway Knowledge Into A Reweighted Recursive Feature Elimination Approach For Risk Stratification Of Cancer Patients. Bioinformatics, 26(17):2136-44.
• Tye-Din JA*, Stewart JA*, Dromey JA*, Beißbarth T* (*equal contributors), van Heel DA, Tatham A, Henderson K, Mannering SI, Gianfrani C, Jewell DP, Hill AV, McCluskey J, Rossjohn J, Anderson RP (2010).
• Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Science Translational Medicine; 2(41):41ra51.
• Fröhlich H, Sahin Ö, Arlt D, Bender C, Beißbarth T (2009). Deterministic Effects Propagation Networks for Reconstructing Protein Signaling Networks from Multiple Interventions. BMC Bioinformatics, 10(1):322.
• Fröhlich H, Tresch A, Beißbarth T (2009). Nested Effects Models for Learning Signaling Networks from Perturbation Data. Biometrical Journal, 51(2):304-23.
• Fröhlich H, Fellmann M, Sültmann H, Poustka A, Beißbarth T (2008). Predicting pathway membership via domain signatures. Bioinformatics; 24(19):2137-42.
• Hahne F, Mehrle A, Arlt D, Poustka A, Wiemann S, Beißbarth T (2008). Extending pathways based on gene lists using InterPro domain signatures. BMC Bioinformatics; 9:3.
• Klemm F*, Bleckmann A*, Siam L, Chuang HN, Rietkötter E, Behme D, Schulz M, Schaffrinski M, Schindler S, Trümper L, Kramer F, Beissbarth T, Stadelmann C, Binder C, Pukrop T. β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis. Carcinogenesis. 2011 Mar;32(3):434-42. Epub 2010 Dec 20. *authors contributed equally
• Conradi LC, Bleckmann A, Schirmer M, Sprenger T, Jo P, Homayounfar K, Wolff HA, Rothe H, Middel P, Becker H, Ghadimi MB, Beissbarth T, Liersch T. Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment. Ann Surg Oncol. 2011 Feb 23. [Epub ahead of print]